DKK2

Chr 4

dickkopf Wnt signaling pathway inhibitor 2

Also known as: DKK-2

NCBI Gene: 27123ENSG00000155011UniProt: Q9UBU2OMIM: 605415

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

GeneReviewsOMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
21
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.47
LOEUF
LOF
Mechanism· predicted
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GeneReview available — DKK2
Authoritative clinical overview · Recommended first read
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.47LOEUF
pLI 0.753
Z-score 2.88
OE 0.15 (0.06–0.47)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
0.42Z-score
OE missense 0.91 (0.79–1.04)
139 obs / 153.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.15 (0.06–0.47)
0≤0.351.4
Missense OE?0.91 (0.79–1.04)
0≤0.61.4
Synonymous OE?0.96
0≤1.21.6
LoF obs/exp: 2 / 13.4Missense obs/exp: 139 / 153.5Syn Z: 0.21

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DKK2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients