DICER1
Chr 14ADdicer 1, ribonuclease III
Also known as: DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Primary Disease Associations & Inheritance
Clinical highlights
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DICER1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Familial Investigations of Childhood Cancer Predisposition
RECRUITINGDICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
RECRUITINGInternational Ovarian & Testicular Stromal Tumor Registry
RECRUITINGGenetic Bases of Neuroendocrine Neoplasms in Mexican Patients
RECRUITINGClinical Genetics Branch Eligibility Screening Survey
NOT YET RECRUITINGInternational PPB/DICER1 Registry
RECRUITINGExternal Resources
Links to major genomics databases and tools