DHRS11

Chr 17

dehydrogenase/reductase 11

Also known as: ARPG836, SDR24C1, spDHRS11

NCBI Gene: 79154ENSG00000278535UniProt: Q6UWP2

Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
6
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.33
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.33LOEUF
pLI 0.000
Z-score 0.71
OE 0.78 (0.48–1.33)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.53Z-score
OE missense 0.87 (0.75–1.02)
122 obs / 139.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.78 (0.48–1.33)
0≤0.351.4
Missense OE?0.87 (0.75–1.02)
0≤0.61.4
Synonymous OE?0.73
0≤1.21.6
LoF obs/exp: 10 / 12.8Missense obs/exp: 122 / 139.5Syn Z: 1.61

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DHRS11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients