DGCR5

Chr 22

DiGeorge syndrome critical region gene 5

Also known as: DGCR10, DGCR9, DGS-A, DGS-B, LINC00037, NCRNA00037, POM121L5P, RIP

NCBI Gene: 26220ENSG00000273032

Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Jul 2025]

195
ClinVar variants
179
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— DGCR5
📋
ClinVar Variants
179 Pathogenic / Likely Pathogenic· 10 VUS of 195 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

195 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic179
VUS10
Likely Benign6
179
Pathogenic
10
VUS
6
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————179
Likely Pathogenic
————0
VUS
————10
Likely Benign
————6
Benign
————0
Total—195

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

DGCR5 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma.
Li Y et al.·Cell Rep
2023
LncRNA DGCR5 promotes lung adenocarcinoma (LUAD) progression via inhibiting hsa-mir-22-3p.
Dong HX et al.·J Cell Physiol
2018
LncRNA DGCR5 Silencing Enhances the Radio-Sensitivity of Human Esophageal Squamous Cell Carcinoma via Negatively Regulating the Warburg Effect.
Wu J et al.·Radiat Res
2023
Long noncoding RNA DGCR5 involves in tumorigenesis of esophageal squamous cell carcinoma via SRSF1-mediated alternative splicing of Mcl-1.
Duan Y et al.·Cell Death Dis
2021
Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma.
Huang R et al.·Cell Physiol Biochem
2016
Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder.
Ghamari M et al.·Metab Brain Dis
2024Cohort
Propofol exerts anticancer activity on hepatocellular carcinoma cells by raising lncRNA DGCR5.
Sun Y et al.·J Cell Physiol
2020
Smoking is Associated with Lung Adenocarcinoma and Lung Squamous Cell Carcinoma Progression through Inducing Distinguishing lncRNA Alterations in Different Genders.
Liu B et al.·Anticancer Agents Med Chem
2022
Long Non-Coding RNA CRNDE Is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling.
Takahashi S et al.·Int J Mol Sci
2021
Identification of a lncRNA‑associated competing endogenous RNA‑regulated network in clear cell renal cell carcinoma.
Liu B et al.·Mol Med Rep
2019
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools