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DEE87
Chr 6ADcyclin dependent kinase 19
Also known as: CDC2L6, CDK11, DEE87, EIEE87, bA346C16.3
This gene encodes a component of the Mediator co-activator complex, which is required for transcriptional activation of genes by RNA polymerase II. Mutations cause developmental and epileptic encephalopathy 87, an autosomal dominant condition characterized by early-onset seizures and developmental impairment. The protein shows similarity to cyclin-dependent kinase 8, another Mediator complex component involved in transcriptional regulation.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/DEE87?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DEE87 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools