DDX43
Chr 6DEAD-box helicase 43
Also known as: CT13, HAGE
The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]
ResearchGenerating clinical summary…
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Moderate LoF intolerance
LoF Constraint?
0.59LOEUF
pLI 0.000
Z-score 3.59
OE 0.38 (0.25–0.59)
More LoF-intolerant than ~75% of genes
Missense Constraint?
1.27Z-score
OE missense 0.81 (0.74–0.90)
303 obs / 371.9 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.38 (0.25–0.59)
0≤0.351.4
Missense OE?0.81 (0.74–0.90)
0≤0.61.4
Synonymous OE?1.05
0≤1.21.6
LoF obs/exp: 15 / 39.3Missense obs/exp: 303 / 371.9Syn Z: -0.48
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DDX43 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools