DDIT4

Chr 10

DNA damage inducible transcript 4

Also known as: Dig2, REDD-1, REDD1

NCBI Gene: 54541ENSG00000168209UniProt: Q9NX09

Predicted to enable 14-3-3 protein binding activity. Involved in negative regulation of TOR signaling and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
143
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.28
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.28LOEUF
pLI 0.001
Z-score 0.99
OE 0.65 (0.35–1.28)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.10Z-score
OE missense 0.97 (0.84–1.13)
130 obs / 133.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.65 (0.35–1.28)
0≤0.351.4
Missense OE?0.97 (0.84–1.13)
0≤0.61.4
Synonymous OE?1.01
0≤1.21.6
LoF obs/exp: 6 / 9.2Missense obs/exp: 130 / 133.4Syn Z: -0.04

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DDIT4 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients