DCP2

Chr 5

decapping mRNA 2

Also known as: NUDT20

NCBI Gene: 167227ENSG00000172795UniProt: Q8IU60OMIM: 609844

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

OMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
0
Active trials
25
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.41
LOEUF
—
Mechanism

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.41LOEUF
pLI 0.664
Z-score 3.75
OE 0.20 (0.10–0.41)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
0.53Z-score
OE missense 0.90 (0.80–1.01)
202 obs / 224.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.20 (0.10–0.41)
0≤0.351.4
Missense OE?0.90 (0.80–1.01)
0≤0.61.4
Synonymous OE?1.24
0≤1.21.6
LoF obs/exp: 5 / 25.4Missense obs/exp: 202 / 224.4Syn Z: -1.65

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

DCP2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients