DCLK2
Chr 4doublecortin like kinase 2
Also known as: CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2
The protein contains doublecortin domains that bind microtubules and regulate microtubule polymerization, plus a serine/threonine protein kinase domain with calcium/calmodulin-dependent activity. Mutations cause lissencephaly with severe epilepsy and early lethality, following an autosomal recessive inheritance pattern. This represents a critical neurodevelopmental disorder affecting cortical formation during fetal brain development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Mild missense constraint
ClinVar Variant Classifications
100 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 0 | 0 | 4 | 0 | 4 |
Likely Pathogenic | 0 | 0 | 0 | 0 | 0 |
VUS | 0 | 70 | 2 | 0 | 72 |
Likely Benign | 0 | 3 | 0 | 3 | 6 |
Benign | 0 | 0 | 0 | 0 | 0 |
| Total | 0 | 73 | 6 | 3 | 82 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
DCLK2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools