DCDC1

Chr 11

doublecortin domain containing 1

Also known as: DCDC5

NCBI Gene: 341019 ENSG00000170959 UniProt: M0R2J8 OMIM: 608062

The protein encoded by DCDC1 is a microtubule-binding protein that mediates dynein-dependent transport of vesicles to the midbody during cell division. Mutations in this gene cause dyslexia susceptibility, with an autosomal dominant inheritance pattern. This gene shows tolerance to loss-of-function variants (pLI near 0), suggesting the clinical phenotype may involve complex genetic mechanisms.

GeneReviews OMIM ResearchSummary from RefSeq, UniProt

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneReviews OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.27

LOEUF

Mechanism· predicted

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GeneReview available — DCDC1