DCAF4L1
Chr 4DDB1 and CUL4 associated factor 4 like 1
Also known as: WDR21B
Located in cytosol. [provided by Alliance of Genome Resources, Jun 2026]
ResearchGenerating clinical summary…
Clinical highlights
Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.12LOEUF
pLI 0.318
Z-score 1.44
OE 0.24 (0.08–1.12)
Highly tolerant — LoF variants common in population
Missense Constraint?
2.23Z-score
OE missense 0.60 (0.52–0.69)
147 obs / 245.3 exp
Moderately missense-constrained (top ~2.5%)
Observed / Expected Ratios?
LoF OE?0.24 (0.08–1.12)
0≤0.351.4
Missense OE?0.60 (0.52–0.69)
0≤0.61.4
Synonymous OE?1.15
0≤1.21.6
LoF obs/exp: 1 / 4.2Missense obs/exp: 147 / 245.3Syn Z: -1.23
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
DCAF4L1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools