DAPL1

Chr 2

death associated protein like 1

NCBI Gene: 92196 ENSG00000163331 UniProt: A0PJW8

Predicted to enable ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Predicted to be involved in several processes, including negative regulation of CD8-positive, alpha-beta T cell activation; negative regulation of autophagy; and ribosome hibernation. Predicted to act upstream of or within cell population proliferation and gene expression. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.88

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.88LOEUF

pLI 0.000

Z-score -0.45

OE 1.22 (0.64–1.88)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

-0.58Z-score

OE missense 1.22 (1.00–1.50)

65 obs / 53.1 exp

Tolerant

Tolerant to missense variation

Observed / Expected Ratios?

LoF OE?1.22 (0.64–1.88)

0≤0.351.4

Missense OE?1.22 (1.00–1.50)

0≤0.61.4

Synonymous OE?1.18

0≤1.21.6

LoF obs/exp: 6 / 4.9Missense obs/exp: 65 / 53.1Syn Z: -0.61

Background carrier burden — how many people carry a rare variant somewhere in DAPL1?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 96

318 rare PASS variants

Rare truncating (LoF)

1 in 690

56 rare PASS variants

Rare synonymous (reference)

1 in 410

115 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for DAPL1. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 110	1 in 740
South Asian	~43k	1 in 140	1 in 410
Remaining (unassigned)	~30k	1 in 81	1 in 700
European (Finnish)	~27k	1 in 540	1 in 990
Admixed American	~22k	1 in 120	1 in 1,200
African / African American	~21k	1 in 85	1 in 670
East Asian	~20k	1 in 200	1 in 970
Ashkenazi Jewish	~13k	1 in 730	≈ 1 in 4,000
Middle Eastern	~2,884	1 in 140	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 4 coding exons well covered in gnomAD exomes and genomes.? see exons ↓