CYP4Z1

Chr 1

cytochrome P450 family 4 subfamily Z member 1

Also known as: CYP4A20

NCBI Gene: 199974ENSG00000186160UniProt: Q86W10

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]

94
ClinVar variants
8
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— CYP4Z1
📋
ClinVar Variants
8 Pathogenic / Likely Pathogenic· 67 VUS of 94 total submissions
Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 502

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

94 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic5
Likely Pathogenic3
VUS67
Likely Benign10
Benign1
5
Pathogenic
3
Likely Pathogenic
67
VUS
10
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
5
0
5
Likely Pathogenic
0
0
3
0
3
VUS
0
66
1
0
67
Likely Benign
0
6
2
2
10
Benign
0
1
0
0
1
Total07311286

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

CYP4Z1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization.
Yuan Y et al.·J Med Chem
2022
Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.
Zheng L et al.·J Hematol Oncol
2019
Stemness-related gene signatures as a predictive tool for breast cancer radiosensitivity.
Lai J et al.·Front Immunol
2025
Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications.
Jarrar YB et al.·Int J Mol Sci
2019Review
Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.
Nguyen HD·Acta Neurol Belg
2025
Fluvastatin suppresses breast cancer initiation and progression via targeting CYP4Z1.
Li H et al.·Commun Biol
2026
Comprehensive Analysis of Transcriptomics and Genetic Alterations Identifies Potential Mechanisms Underlying Anthracycline Therapy Resistance in Breast Cancer.
Liu Z et al.·Biomolecules
2022Functional
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition.
Kowalski JP et al.·Xenobiotica
2021
A search for reliable molecular markers of prognosis in prostate cancer: a study of 240 cases.
Tradonsky A et al.·Am J Clin Pathol
2012Cohort
Identification of the Characteristic Genes and their Roles in Lung Adenocarcinoma Lymph Node Metastasis through Machine Learning Algorithm.
Zhou Q et al.·Comput Math Methods Med
2022
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools