CYP2C9
Chr 10cytochrome P450 family 2 subfamily C member 9
Also known as: CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CYP2C9 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
ACTIVE NOT RECRUITINGPralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors
RECRUITINGCELECOXIB Plasma and Cerebral Spinal Fluid Pharmacokinetics in Children
RECRUITINGPilot-Study for the Comparison of Biomarkers Between Regular Cannabis Users and Non-Users
RECRUITINGEarly Post-Traumatic Seizures Prevention Trial (E-PTS Trial)
RECRUITINGPharmacogenetics-Based Study on Individualized Use of Sodium Valproate
RECRUITINGAn European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis
RECRUITINGPrecision Medicine in the Treatment of Epilepsy
RECRUITINGBiological Collection for the Purpose of Exploring Genetic and Clinical-biological Factors Associated With Variability in Response to Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy
NOT YET RECRUITINGTHC Titration of High-Potency Cannabis Concentrates
RECRUITINGTelecommunication Technology-based Online Survey
RECRUITINGREGistry of Long-term AnTithrombotic TherApy-2
RECRUITINGExternal Resources
Links to major genomics databases and tools