CYP2C19
Chr 10ARcytochrome P450 family 2 subfamily C member 19
Also known as: CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Primary Disease Associations & Inheritance
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CYP2C19 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
CYP2C19 Variants and Limonene Metabolism
RECRUITINGFENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
NOT YET RECRUITINGPrecision PCI Registry
ACTIVE NOT RECRUITINGThe Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate）and Plavix® in Healthy Participants
RECRUITINGREGistry of Long-term AnTithrombotic TherApy-1
RECRUITINGPolygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
ACTIVE NOT RECRUITINGPOPular GUILTY PILOT: Genotype-guided Clopidogrel Monotherapy
RECRUITINGPharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
RECRUITINGIdentification of New Tools for Predicting Natural Metabolic Performance of the Liver
RECRUITINGPharmacogenetic Testing at Community Pharmacy
NOT YET RECRUITINGPilot-Study for the Comparison of Biomarkers Between Regular Cannabis Users and Non-Users
RECRUITINGCYP2C19 Genotype-Guided P2Y12 Receptor Inhibitor Selection After Complex Percutaneous Coronary Intervention
RECRUITINGExternal Resources
Links to major genomics databases and tools