CXORF58
Chr Xchromosome X open reading frame 58
This gene encodes a protein of unknown function located on the X chromosome. Mutations cause X-linked intellectual disability, and the gene shows minimal constraint against loss-of-function variants (very low pLI score). The clinical phenotype and inheritance pattern suggest X-linked recessive inheritance affecting primarily males.
Some data sources returned errors (1)
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Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CXORF58 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools