CXCL6

Chr 4

C-X-C motif chemokine ligand 6

Also known as: CKA-3, GCP-2, GCP2, SCYB6

NCBI Gene: 6372ENSG00000124875UniProt: P80162OMIM: 138965

CXCL6 encodes a CXC chemokine that attracts neutrophils through CXCR1 and CXCR2 receptors and has antibacterial activity against gram-positive and gram-negative bacteria. The gene is not highly constrained against loss-of-function variants, and no Mendelian diseases have been definitively associated with CXCL6 mutations in current databases. This chemokine is part of a gene cluster on chromosome 4q involved in innate immune responses.

OMIMResearchSummary from RefSeq, UniProt
DNmechanismLOEUF 1.97
Clinical Summary— CXCL6
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint
1.97LOEUF
pLI 0.000
Z-score -2.30
OE 2.15 (1.10–1.97)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.68Z-score
OE missense 1.24 (1.03–1.49)
81 obs / 65.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE2.15 (1.10–1.97)
0≤0.351.4
Missense OE1.24 (1.03–1.49)
0≤0.61.4
Synonymous OE1.23
0≤1.21.6
LoF obs/exp: 10 / 4.6Missense obs/exp: 81 / 65.5Syn Z: -1.03
DN
0.74top 25%
GOF
0.6248th %ile
LOF
0.2484th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CXCL6 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold
Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Comparative analysis of salivary IL-4 and CXCL6 dynamics following tooth extraction in diabetic and non-diabetic patients.
Alsaegh MA et al.·Med Oral Patol Oral Cir Bucal
2026Cohort
Serum CXCL6 as a biomarker for diagnosing and predicting progression of interstitial lung disease in ANCA-associated vasculitis.
Li W et al.·Arthritis Res Ther
2025Open Access
Thrombomodulin and CXCL6 Altered Expression in Preeclampsia: Serum-Placental Biomarker Correlations and Clinical Significance.
Lai X et al.·Am J Reprod Immunol
2025
Correction: Lee et al. Tumor-Associated Macrophages Affect the Tumor Microenvironment and Radioresistance via the Upregulation of CXCL6/CXCR2 in Hepatocellular Carcinoma. Biomedicines 2023, 11, 2081.
Lee HL et al.·Biomedicines
2025Open Access
Clinical significance of the CXCL6-CXCR1/CXCR2 chemokine signaling pathway in the peritoneal fluid of patients with endometriosis.
Smycz-Kubanska M et al.·Ginekol Pol
2025Cohort
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients