CXCL6

Chr 4

C-X-C motif chemokine ligand 6

Also known as: CKA-3, GCP-2, GCP2, SCYB6

NCBI Gene: 6372 ENSG00000124875 UniProt: P80162

CXCL6 encodes a CXC chemokine that attracts neutrophils through CXCR1 and CXCR2 receptors and has antibacterial activity against gram-positive and gram-negative bacteria. The gene is not highly constrained against loss-of-function variants, and no Mendelian diseases have been definitively associated with CXCL6 mutations in current databases. This chemokine is part of a gene cluster on chromosome 4q involved in innate immune responses.

ResearchSummary from RefSeq, UniProt

The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]

ResearchGenerating clinical summary…

Active trials

103

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.97

LOEUF

Mechanism· predicted

Some data sources returned errors (1)