CXCL5

Chr 4

C-X-C motif chemokine ligand 5

Also known as: ENA-78, SCYB5

NCBI Gene: 6374 ENSG00000163735 UniProt: P42830

Encodes epithelial neutrophil-activating peptide 78 (ENA-78), a chemokine that recruits and activates neutrophils through binding to CXCR2 receptor and promotes angiogenesis and tissue remodeling. No pediatric neurologic diseases have been associated with mutations in this gene based on the available data. This gene shows very low constraint against loss-of-function variants (pLI near 0, LOEUF 1.9), indicating tolerance to protein-truncating mutations.

ResearchSummary from RefSeq, UniProt

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

ResearchGenerating clinical summary…

Active trials

291

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.91

LOEUF

Mechanism· predicted

Some data sources returned errors (1)