CXCL3

Chr 4

C-X-C motif chemokine ligand 3

Also known as: CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3

NCBI Gene: 2921ENSG00000163734UniProt: P19876

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

ResearchGenerating clinical summary…
1
Active trials
119
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.85
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.85LOEUF
pLI 0.000
Z-score -0.17
OE 1.08 (0.55–1.85)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.72Z-score
OE missense 1.28 (1.05–1.58)
66 obs / 51.4 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.08 (0.55–1.85)
0≤0.351.4
Missense OE?1.28 (1.05–1.58)
0≤0.61.4
Synonymous OE?1.30
0≤1.21.6
LoF obs/exp: 5 / 4.6Missense obs/exp: 66 / 51.4Syn Z: -1.13

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CXCL3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients