CXCL3
Chr 4C-X-C motif chemokine ligand 3
Also known as: CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
The protein is a secreted chemokine that functions as a chemoattractant for neutrophils and signals through the CXCR2 receptor to mediate inflammatory responses. This gene is not loss-of-function intolerant (pLI = 0.0003, LOEUF = 1.848), and no well-established Mendelian diseases have been linked to CXCL3 mutations in current genetic databases.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CXCL3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
External Resources
Links to major genomics databases and tools