CXCL13

Chr 4

C-X-C motif chemokine ligand 13

Also known as: ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13

NCBI Gene: 10563 ENSG00000156234 UniProt: O43927 OMIM: 605149

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

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P/LP submissions

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P/LP missense

0.52

LOEUF

Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance

LoF Constraint?

0.52LOEUF

pLI 0.826

Z-score 2.22

OE 0.00 (0.00–0.52)

Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?

0.58Z-score

OE missense 0.79 (0.62–1.00)

46 obs / 58.5 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.00 (0.00–0.52)

0≤0.351.4

Missense OE?0.79 (0.62–1.00)

0≤0.61.4

Synonymous OE?0.95

0≤1.21.6

LoF obs/exp: 0 / 5.8Missense obs/exp: 46 / 58.5Syn Z: 0.18

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CXCL13 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox

AI-powered variant curation and clinical analysis

Genomic variants and phenotypes in rare disease patients

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

Central Nervous System Lymphoma

Selinexor in Combination With MTX+Ritu to Treat R/R CNSL

NCT05698147Phase PHASE1, PHASE2Tong Chen, MDStarted 2023-08-03

SelinexorRituximabMethotrexate

Helicobacter Pylori Infection

A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile

NCT05926804Phase NAMiguel O'Ryan GallardoStarted 2022-08-02

LansoprazoleAmoxicillinClarithromycin

Locally Advanced Bladder Urothelial CarcinomaLocally Advanced Renal Pelvis Urothelial CarcinomaLocally Advanced Ureter Urothelial Carcinoma

ARID1A and/or KDM6A Mutation and CXCL13 Expression

ACTIVE NOT RECRUITING

NCT04953104Phase PHASE2M.D. Anderson Cancer CenterStarted 2021-09-21

Diagnostic Laboratory Biomarker AnalysisNivolumabRelatlimab

Waldenstrom's DiseaseWaldenstrom Macroglobulinemia

Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia

NCT04893564Phase NACentre Hospitalier Universitaire, AmiensStarted 2022-05-16

bone marrow sampleblood sample

Breast CancerCentral Nervous System Metastases

Predictive Factors for CNS Metastases in Early Breast Cancer Using Liquid Biopsy (AKRA CŽS)

ACTIVE NOT RECRUITING

NCT07447544Phase NAInstitute of Oncology LjubljanaStarted 2025-07-07

Primary Tumor mRNA Expression Profiling (NGS)Serum Chemokine Quantification (ELISA)

External Resources

Links to major genomics databases and tools

Franklin by Genoox

AI-powered variant curation and clinical analysis

Genomic variants and phenotypes in rare disease patients