CXCL11
Chr 4C-X-C motif chemokine ligand 11
Also known as: H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1
The protein encoded by this gene is a chemokine that recruits activated T-cells through binding to the CXCR3 receptor and plays a role in central nervous system immune responses. Currently, no Mendelian diseases have been definitively associated with mutations in CXCL11 in pediatric populations. The gene shows tolerance to loss-of-function variants (pLI 0.31, LOEUF 1.14), suggesting haploinsufficiency is unlikely to cause severe developmental phenotypes.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CXCL11 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools