CXCL10

Chr 4

C-X-C motif chemokine ligand 10

Also known as: C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1

NCBI Gene: 3627ENSG00000169245UniProt: P02778

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]

GeneReviewsResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.
12
Active trials
1471
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.00
LOEUF
DN
Mechanism· predicted
📖
GeneReview available — CXCL10
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.00LOEUF
pLI 0.369
Z-score 1.59
OE 0.21 (0.07–1.00)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.34Z-score
OE missense 0.87 (0.68–1.11)
45 obs / 51.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.21 (0.07–1.00)
0≤0.351.4
Missense OE?0.87 (0.68–1.11)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 1 / 4.7Missense obs/exp: 45 / 51.8Syn Z: 0.59

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CXCL10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
SARS CoV 2 InfectionSARS CoV 2 Vaccination

COVID-19 Transmission and Morbidity in Malawi

RECRUITING
NCT05973084Boston UniversityStarted 2023-01-17
DysferlinopathyMiyoshi MyopathyLGMDR2

Clinical, Immunological, Morphological and Genetic Characteristics of Patients With Dysferlinopathy (LGMD R2) in the RF

ENROLLING BY INVITATION
NCT04824040Artgen BiotechStarted 2020-01-15
Kidney TransplantRejection

Detection of Circulating Kidney DNA in Kidney Transplant Patients Facing an Episode of Graft Rejection

RECRUITING
NCT06351488Assistance Publique - Hôpitaux de ParisStarted 2024-08-21
Extrapulmonary Tuberculosis

A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis

RECRUITING
NCT06875336University of CologneStarted 2023-03-06
biomarker analysis
Porphyria, Acute Intermittent

Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment

RECRUITING
NCT06273644Phase NANordlandssykehuset HFStarted 2024-01-27
Carbohydrates
Central Centrifugal Cicatricial AlopeciaFrontal Fibrosing Alopecia

Deucravacitinib in the Treatment of Cicatricial Alopecias

RECRUITING
NCT07508488Phase PHASE2Icahn School of Medicine at Mount SinaiStarted 2026-05-28
Deucravacitinib
Head and Neck Squamous Cell CarcinomaSoft Tissue Sarcoma AdultTriple Negative Breast Cancer

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

RECRUITING
NCT06700070Phase EARLY_PHASE1Pure Biologics S.A.Started 2025-03-27
PBA-0111
Immune Thrombocytopenic Purpura ( ITP )Systemic Lupus Erythematosus (SLE)

Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus

NOT YET RECRUITING
NCT07680010Phase NAUniversity Hospital, BordeauxStarted 2026-07
Blood sampling baseline and M3Monitoring for SLEProcedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months
Highly Sensitized Patients Awaiting Kidney Transplant

OM336 in Sensitized Transplant Candidates

NOT YET RECRUITING
NCT07789431Phase PHASE2Medical University of ViennaStarted 2026-10-01
OM3436
Endometriosis

Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care

RECRUITING
NCT06331676Phase NAHospices Civils de LyonStarted 2024-06-21
Tissue collectionData collection
Chronic Obstructive Pulmonary Disease Exacerbation

The CATALINA Study

RECRUITING
NCT05008081Wim JanssensStarted 2022-10-25
Solid Tumor

A Clinical Study of the Safety and Effectiveness of an Investigational Cell Therapy Given With and Without an Investigational RNA-based Vaccine in Patients With Organ Tumors

ACTIVE NOT RECRUITING
NCT04503278Phase PHASE1BioNTech Cell & Gene Therapies GmbHStarted 2020-09-16
CLDN6 CAR-TCLDN6 uRNA-LPX/CLDN6 modRNA-LPX

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients