CXCL10

Chr 4

C-X-C motif chemokine ligand 10

Also known as: C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1

NCBI Gene: 3627ENSG00000169245UniProt: P02778OMIM: 147310

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]

OMIMResearchGenerating clinical summary…
DNmechanismLOEUF 1.00
Clinical Summary— CXCL10
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Population Constraint (gnomAD)
Constrained for loss-of-function variants (OE-LoF 0.21) despite low pLI — interpret in context.
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Clinical Trials
12 active or recruiting trials — potential therapeutic options may be available
Explore recent and relevant literature in Research Assistant →

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.00LOEUF
pLI 0.369
Z-score 1.59
OE 0.21 (0.07–1.00)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.34Z-score
OE missense 0.87 (0.68–1.11)
45 obs / 51.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.21 (0.07–1.00)
0≤0.351.4
Missense OE?0.87 (0.68–1.11)
0≤0.61.4
Synonymous OE?0.81
0≤1.21.6
LoF obs/exp: 1 / 4.7Missense obs/exp: 45 / 51.8Syn Z: 0.59

This gene — mechanism propensity

DN
0.6840th %ile
GOF
0.3788th %ile
LOF
0.2873th %ile

The highest-scoring mechanism for this gene is dominant-negative.

DNprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CXCL10 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Extrapulmonary Tuberculosis

A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis

RECRUITING
NCT06875336University of CologneStarted 2023-03-06
biomarker analysis
SARS CoV 2 InfectionSARS CoV 2 Vaccination

COVID-19 Transmission and Morbidity in Malawi

RECRUITING
NCT05973084Boston UniversityStarted 2023-01-17
Head and Neck Squamous Cell CarcinomaSoft Tissue Sarcoma AdultTriple Negative Breast Cancer

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

RECRUITING
NCT06700070Phase EARLY_PHASE1Pure Biologics S.A.Started 2025-03-27
PBA-0111
Immune Thrombocytopenic Purpura ( ITP )Systemic Lupus Erythematosus (SLE)

Model Early Immunologic Stages of Pediatric Hematological Pre-lupus

NOT YET RECRUITING
NCT07680010Phase NAUniversity Hospital, BordeauxStarted 2026-07
Blood sampling baseline and M3Monitoring for SLEProcedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months
COVID-19Influenza

Clinical Study on the Immune Response Characteristics of Novel Coronavirus and Influenza Virus Infection

RECRUITING
NCT06667063Zhongnan HospitalStarted 2024-09-19
Nasal swab/Nasopharyngeal swab/Blood sample collectionNasal swab/Nasopharyngeal swab/Blood drawNasal swab/Nasopharyngeal swab/Blood draw
Fatty Liver

Effects of Compound Probiotics-Polygonatum Sibiricum on Liver Health and Metabolism in Middle-aged and Elderly People

NOT YET RECRUITING
NCT06873412Phase NAWecare Probiotics Co., Ltd.Started 2025-03-10
ProbioticPlacbo
Hand OsteoarthritisErosive Osteoarthritis

Methotrexate in Erosive Inflammatory Hand Osteoarthritis

ACTIVE NOT RECRUITING
NCT04579848Phase PHASE4Diakonhjemmet HospitalStarted 2021-08-12
Methotrexate TabletsPlaceboFolic Acid 1 MG
Recurrent Glioblastoma

Tris-CAR-T Cell Therapy for Recurrent Glioblastoma

RECRUITING
NCT05577091Phase PHASE1Beijing Tiantan HospitalStarted 2023-09-30
Inverse correlated dual-target, truncated IL7Ra modified CAR -expressing autologous T-lymphocytes.
Viral InfectionSepsis

COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit

ACTIVE NOT RECRUITING
NCT05671159Phase NAUniversity Hospital, LimogesStarted 2023-02-19
Blood sample
Renal Allograft Fibrosis

Renal Allograft Fibrosis Study

ENROLLING BY INVITATION
NCT05058170Icahn School of Medicine at Mount SinaiStarted 2022-02-04
Cutaneous Squamous Cell Carcinoma (CSCC)

Next-gen Flow Cytometry to Find Immune Profiles, Treatment Response, and Toxicity Markers in Skin Cancer Patients Treated With Cemiplimab.

RECRUITING
NCT07064330Instituto de Investigación Biomédica de SalamancaStarted 2025-07-17
Cemiplimab
Central Centrifugal Cicatricial AlopeciaFrontal Fibrosing Alopecia

Deucravacitinib in the Treatment of Cicatricial Alopecias

RECRUITING
NCT07508488Phase PHASE2Icahn School of Medicine at Mount SinaiStarted 2026-05-28
Deucravacitinib

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients