CWF19L1

Chr 10

CWF19 like cell cycle control factor 1

Also known as: C19L1, SCAR17, hDrn1

This gene encodes a member of the CWF19 protein family. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia-17 and mild cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

UniProtSpinocerebellar ataxia, autosomal recessive, 17

Clinical highlights

Gene-disease validity (ClinGen)
autosomal recessive cerebellar ataxia · ARDefinitivesufficient evidence for diagnostic panels
0
Active trials
1
Pubs (1 yr)
P/LP submissions
P/LP missense
1.15
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.15LOEUF
pLI 0.000
Z-score 0.89
OE 0.83 (0.611.15)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
1.10Z-score
OE missense 0.82 (0.730.91)
232 obs / 283.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.83 (0.611.15)
00.351.4
Missense OE?0.82 (0.730.91)
00.61.4
Synonymous OE?0.87
01.21.6
LoF obs/exp: 26 / 31.4Missense obs/exp: 232 / 283.9Syn Z: 1.01

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CWF19L1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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