CRISP2

Chr 6

cysteine rich secretory protein 2

Also known as: CRISP-2, CT36, GAPDL5, TPX1, TSP1

Predicted to be located in extracellular region. Predicted to be active in obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
10
Pubs (1 yr)
P/LP submissions
P/LP missense
1.68
LOEUF
GOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.68LOEUF
pLI 0.000
Z-score -0.49
OE 1.14 (0.781.68)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.46Z-score
OE missense 1.11 (0.971.28)
143 obs / 128.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.14 (0.781.68)
00.351.4
Missense OE?1.11 (0.971.28)
00.61.4
Synonymous OE?0.95
01.21.6
LoF obs/exp: 17 / 15.0Missense obs/exp: 143 / 128.5Syn Z: 0.30

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CRISP2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →