CRAMP1

Chr 16

cramped chromatin regulator 1

Also known as: CRAMP1L, HN1L, TCE4

NCBI Gene: 57585 ENSG00000007545 UniProt: Q96RY5

This protein is a transcription factor that drives expression of histone H1 genes by binding to their promoters together with NPAT and GON4L. The gene is highly constrained against loss-of-function variants (LOEUF 0.417), but no associated human disease has been reported to date. Clinical significance of variants in this gene remains to be established.

ResearchSummary from RefSeq, UniProt

Enables DNA-binding transcription factor activity. Involved in positive regulation of DNA-templated transcription. Is active in histone locus body. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

0.42

LOEUF

LOF

Mechanism· predicted

Some data sources returned errors (1)

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