CPXM2

Chr 10

carboxypeptidase X, M14 family member 2

Also known as: CPX2, UNQ676

NCBI Gene: 119587ENSG00000121898UniProt: Q8N436OMIM: 617348

Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
—
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.95
LOEUF
DN
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.95LOEUF
pLI 0.000
Z-score 1.81
OE 0.68 (0.49–0.95)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.17Z-score
OE missense 0.98 (0.91–1.06)
457 obs / 467.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.68 (0.49–0.95)
0≤0.351.4
Missense OE?0.98 (0.91–1.06)
0≤0.61.4
Synonymous OE?0.90
0≤1.21.6
LoF obs/exp: 25 / 36.9Missense obs/exp: 457 / 467.4Syn Z: 1.03

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CPXM2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients