CORO7-PAM16
Chr 16CORO7-PAM16 readthrough
This gene encodes a fusion protein that combines sequences from coronin 7 (involved in actin cytoskeleton regulation) and PAM16 (a component of the mitochondrial protein import machinery). The gene is extremely intolerant to loss-of-function variants (pLI near 1.0), but associated diseases and inheritance patterns have not been established. Clinical significance of variants in this read-through transcript remains unclear.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CORO7-PAM16 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools