COMT
Chr 22catechol-O-methyltransferase
Also known as: HEL-S-98n
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Primary Disease Associations & Inheritance
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
COMT · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy
RECRUITINGHome-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)
RECRUITINGEffect of Sleep Extension in Prevention to Sleep Deprivation
RECRUITINGStudy of Atomoxetine in the Prevention of Vasovagal Syncope
RECRUITINGEfficacy of a Prediction Model-based Algorithm to PREVENT Drug-induced Impulse Control Disorders in Parkinson's Disease
NOT YET RECRUITINGModulation of THC Effects by CBD: a Dose-ranging Study
RECRUITINGREACT MCI - Repeated Advanced Cognitive Training in Mild Cognitive Impairment
ACTIVE NOT RECRUITINGEvaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
ACTIVE NOT RECRUITINGPhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia
NOT YET RECRUITINGPersonalized Perioperative Analgesia Platform (PPAP) for Pediatric Spine Fusion Surgery (sIRB)
RECRUITINGEvaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.
RECRUITINGThe Meaning of Dopaminergic Pathway in Sleep Breathing Disorders.
ENROLLING BY INVITATIONExternal Resources
Links to major genomics databases and tools