COMMD3-BMI1

Chr 10

COMMD3-BMI1 readthrough

Also known as: PCGF4, RNF51

This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
P/LP submissions
P/LP missense
0.60
LOEUF
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Moderate LoF intolerance
LoF Constraint?
0.60LOEUF
pLI 0.001
Z-score 3.18
OE 0.35 (0.220.60)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
1.90Z-score
OE missense 0.66 (0.580.75)
163 obs / 247.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.35 (0.220.60)
00.351.4
Missense OE?0.66 (0.580.75)
00.61.4
Synonymous OE?1.15
01.21.6
LoF obs/exp: 10 / 28.3Missense obs/exp: 163 / 247.2Syn Z: -1.06

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

COMMD3-BMI1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →