COLEC10
Chr 8ARcollectin subfamily member 10
Also known as: 3MC3, CL-10, CL-34, CLL1
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
This gene — mechanism propensity
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
64 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 3 | 1 | 1 | 0 | 5 |
Likely Pathogenic | 1 | 1 | 0 | 0 | 2 |
VUS | 0 | 43 | 1 | 0 | 44 |
Likely Benign | 0 | 4 | 0 | 4 | 8 |
Benign | 0 | 0 | 1 | 2 | 3 |
| Total | 4 | 49 | 3 | 6 | 62 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →55 pathogenic / likely-pathogenic (of 63) ClinVar copy-number / structural variants overlap COLEC10 — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →
Protein Context — Lollipop Plot
COLEC10 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Clinical Study of CLL-1 CAR-T in the Treatment of Children With R/R AML
NOT YET RECRUITINGBG1805 Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia in Children
NOT YET RECRUITINGMulti-CAR T Cell Therapy for Acute Myeloid Leukemia
RECRUITINGPhase I Clinical Study: BG1805 Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
RECRUITINGA Clinical Study to Evaluate the Safety and Efficacy of CLL1 and CD38 Dual-Target CAR-T Cell Injection in the Treatment of Relapsed or Refractory Acute Myeloid Leukemia
RECRUITINGMultiple CAR-T Cell Therapy Targeting AML
RECRUITINGAnti-CD33-CLL1 CAR-T Cells (ICG415) for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
RECRUITINGClinical Study on the Safety, Efficacy and Pharmacokinetics of Universal CLL1 Chimeric Antigen Receptor T-Cell in Relapsed/Refractory Acute Myeloid Leukemia
NOT YET RECRUITINGChimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools