CNR1
Chr 6cannabinoid receptor 1
Also known as: CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Primary Disease Associations & Inheritance
Some data sources returned errors (2)
gnomad: TimeoutError: The operation was aborted due to timeout
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CNR1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
IMarkHD: in Vivo Longitudinal Imaging of HD Pathology
RECRUITINGPilot-Study for the Comparison of Biomarkers Between Regular Cannabis Users and Non-Users
RECRUITINGImaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
RECRUITINGTHC Titration of High-Potency Cannabis Concentrates
RECRUITINGPharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
RECRUITINGExternal Resources
Links to major genomics databases and tools