CNPY3-GNMT
Chr 6CNPY3-GNMT readthrough
This locus represents naturally occurring readthrough transcription between the upstream CNPY3 (canopy FGF signaling regulator 3) and the downstream GNMT (glycine N-methyltransferase) genes. Readthrough transcripts may encode proteins that have amino acid similarity with proteins encoded by both individual genes. [provided by RefSeq, Jan 2016]
Some data sources returned errors (3)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/CNPY3-GNMT?content-type=application/json&expand=1
clinvar: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
214 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 2 | 3 | 5 | 0 | 10 |
Likely Pathogenic | 2 | 0 | 2 | 0 | 4 |
VUS | 5 | 124 | 7 | 1 | 137 |
Likely Benign | 0 | 4 | 13 | 24 | 41 |
Benign | 0 | 1 | 14 | 4 | 19 |
Conflicting | — | 3 | |||
| Total | 9 | 132 | 41 | 29 | 214 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
CNPY3-GNMT · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype
No OMIM entries found.
External Resources
Links to major genomics databases and tools
Variant Interpretation
Population Databases
Gene Resources
Expert Curation
No publications found for CNPY3-GNMT
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools