CLUL1

Chr 18

clusterin like 1

Also known as: RA337M

NCBI Gene: 27098ENSG00000079101UniProt: Q15846

Predicted to enable misfolded protein binding activity. Predicted to be located in extracellular region. Predicted to be active in nucleus and obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.31
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.31LOEUF
pLI 0.000
Z-score 0.49
OE 0.88 (0.61–1.31)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.64Z-score
OE missense 0.88 (0.79–0.99)
212 obs / 239.8 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.88 (0.61–1.31)
0≤0.351.4
Missense OE?0.88 (0.79–0.99)
0≤0.61.4
Synonymous OE?1.15
0≤1.21.6
LoF obs/exp: 18 / 20.4Missense obs/exp: 212 / 239.8Syn Z: -1.08

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CLUL1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients