CLEC9A

Chr 12

C-type lectin domain containing 9A

Also known as: CD370, DNGR-1, DNGR1, UNQ9341

NCBI Gene: 283420 ENSG00000197992 UniProt: Q6UXN8

CLEC9A encodes a C-type lectin-like receptor that functions as an endocytic receptor on specialized myeloid cells, recognizing filamentous actin from damaged cell membranes to facilitate uptake and cross-presentation of antigens from dead cells. This gene is extremely tolerant to loss-of-function variants in the general population, but no established Mendelian disease associations have been reported in the provided data.

ResearchSummary from RefSeq, UniProt

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.21

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)