CLDND1
Chr 3claudin domain containing 1
Also known as: C3orf4, CLDN-25, GENX-3745, Z38
Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
Clinical highlights
Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Curated gene-level mechanism — a prior for triage, not a per-variant call.
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.62LOEUF
pLI 0.164
Z-score 2.61
OE 0.27 (0.13–0.62)
Typical tolerance to LoF variation
Missense Constraint?
0.09Z-score
OE missense 0.98 (0.86–1.12)
155 obs / 158.2 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.27 (0.13–0.62)
0≤0.351.4
Missense OE?0.98 (0.86–1.12)
0≤0.61.4
Synonymous OE?1.08
0≤1.21.6
LoF obs/exp: 4 / 14.8Missense obs/exp: 155 / 158.2Syn Z: -0.47
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CLDND1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools