CLASP1
Chr 2cytoplasmic linker associated protein 1
Also known as: MAST1
CLASP1 encodes a microtubule plus-end tracking protein that stabilizes dynamic microtubules and is essential for proper chromosome alignment during cell division. The gene is highly constrained against loss-of-function variants (pLI ~1.0, LOEUF 0.176), suggesting mutations would likely cause severe developmental consequences. However, no specific genetic disorders have been definitively associated with CLASP1 mutations in humans to date.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Highly missense-constrained (top ~0.1%)
The highest-scoring mechanism for this gene is loss-of-function (haploinsufficiency).
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312. Mechanism ranking also informed by gnomAD constraint, ClinVar, and ClinGen data.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CLASP1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools