CKS2
Chr 9CDC28 protein kinase regulatory subunit 2
Also known as: CKSHS2
The CKS2 protein binds to the catalytic subunit of cyclin dependent kinases and is essential for their biological function in cell cycle regulation. Mutations in CKS2 cause autosomal recessive neurodevelopmental disorder with microcephaly and growth retardation. The inheritance pattern is autosomal recessive.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CKS2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools