CIP2A

Chr 3

cellular inhibitor of PP2A

Also known as: KIAA1524, NOCIVA, p90

Enables protein homodimerization activity and protein phosphatase inhibitor activity. Involved in broken chromosome clustering. Located in several cellular components, including cytosol; microtubule organizing center; and plasma membrane. Is active in chromosome. [provided by Alliance of Genome Resources, Apr 2025]

GeneReviewsResearchGenerating clinical summary…
0
Active trials
44
Pubs (1 yr)
P/LP submissions
P/LP missense
0.84
LOEUF
Mechanism
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GeneReview available — CIP2A
Authoritative clinical overview · Recommended first read
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
0.84LOEUF
pLI 0.000
Z-score 2.44
OE 0.61 (0.450.84)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.67Z-score
OE missense 0.91 (0.840.99)
401 obs / 440.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.61 (0.450.84)
00.351.4
Missense OE?0.91 (0.840.99)
00.61.4
Synonymous OE?1.11
01.21.6
LoF obs/exp: 28 / 45.9Missense obs/exp: 401 / 440.5Syn Z: -1.06

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CIP2A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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