CIP2A
Chr 3cellular inhibitor of PP2A
Also known as: KIAA1524, NOCIVA, p90
The protein inhibits protein phosphatase PP2A and, together with TOPBP1, facilitates clustering of chromosome fragments during mitosis to maintain genome stability. Mutations cause an autosomal recessive neurodevelopmental disorder characterized by intellectual disability, microcephaly, and seizures. The gene shows minimal constraint against loss-of-function variants based on population data.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CIP2A · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools