CIMIP2A

Chr 9

ciliary microtubule inner protein 2A

Also known as: FAM166A, HSD46

The protein is a microtubule inner protein that binds to intra-tubulin interfaces within dynein-decorated doublet microtubules in flagellar axonemes and is involved in flagellated sperm motility. Mutations cause primary ciliary dyskinesia with an autosomal recessive inheritance pattern. The gene shows minimal constraint against loss-of-function variants based on population genetics data.

ResearchSummary from RefSeq, UniProt
LOEUF 1.66
Clinical SummaryCIMIP2A
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.66LOEUF
pLI 0.000
Z-score -0.42
OE 1.12 (0.761.66)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-2.21Z-score
OE missense 1.44 (1.311.59)
287 obs / 199.3 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE1.12 (0.761.66)
00.351.4
Missense OE1.44 (1.311.59)
00.61.4
Synonymous OE1.33
01.21.6
LoF obs/exp: 17 / 15.2Missense obs/exp: 287 / 199.3Syn Z: -2.36

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CIMIP2A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 4 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found