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CHIME

Chr 17AR

phosphatidylinositol glycan anchor biosynthesis class L

Also known as: CHIME

The encoded enzyme catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis by de-N-acetylating N-acetylglucosaminylphosphatidylinositol in the endoplasmic reticulum. Mutations cause CHIME syndrome, a multisystem disorder affecting colobomas, heart defects, ichthyosiform dermatosis, intellectual disability, and ear abnormalities. Inheritance is autosomal recessive.

OMIMResearchSummary from RefSeq, OMIM
AR1 OMIM phenotype
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/CHIME?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CHIME · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

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