CFLAR

Chr 2

CASP8 and FADD like apoptosis regulator

The protein encoded by CFLAR regulates apoptosis by inhibiting TNFRSF6-mediated cell death and blocking caspase-8 processing in the death-inducing signaling complex. Mutations cause autosomal recessive immunodeficiency with recurrent infections, lymphoproliferation, and autoimmunity. The gene is highly constrained against loss-of-function variants, indicating that biallelic mutations are required for disease.

OMIMResearchSummary from RefSeq, UniProt
LOEUF 0.17
Clinical SummaryCFLAR
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 1.00). One damaged copy is likely sufficient to cause disease.
Some data sources returned errors (1)

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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

LoF intolerant — likely haploinsufficient
LoF Constraint
0.17LOEUF
pLI 1.000
Z-score 4.67
OE 0.04 (0.010.17)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint
2.19Z-score
OE missense 0.61 (0.540.70)
154 obs / 251.6 exp
Mild constraint

Moderately missense-constrained (top ~2.5%)

Observed / Expected Ratios
LoF OE0.04 (0.010.17)
00.351.4
Missense OE0.61 (0.540.70)
00.61.4
Synonymous OE0.87
01.21.6
LoF obs/exp: 1 / 27.4Missense obs/exp: 154 / 251.6Syn Z: 1.03

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CFLAR · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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