CFAP61
Chr 20ARcilia and flagella associated protein 61
Also known as: C20orf26, CaM-IP3, SPGF84, dJ1002M8.3, dJ1178H5.4
The CFAP61 protein is involved in sperm flagellum assembly and plays an essential role in the formation of radial spokes in flagellum axoneme. Mutations cause spermatogenic failure 84, which follows autosomal recessive inheritance. This gene primarily affects male fertility rather than neurological development.
Primary Disease Associations & Inheritance
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CFAP61 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools