CER1

Chr 9

cerberus 1, DAN family BMP antagonist

Also known as: DAND4

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
Pubs (1 yr)
P/LP submissions
P/LP missense
1.80
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.80LOEUF
pLI 0.000
Z-score -0.15
OE 1.06 (0.601.80)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.64Z-score
OE missense 1.38 (1.231.55)
203 obs / 147.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.06 (0.601.80)
00.351.4
Missense OE?1.38 (1.231.55)
00.61.4
Synonymous OE?1.26
01.21.6
LoF obs/exp: 7 / 6.6Missense obs/exp: 203 / 147.1Syn Z: -1.55

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

CER1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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