CEMIP2
Chr 9cell migration inducing hyaluronidase 2
Also known as: TMEM2
The protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into smaller fragments and has interferon-mediated antiviral activity. Mutations cause autosomal recessive non-syndromic hearing loss. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.644).
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CEMIP2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools