CDY2B
Chr Ychromodomain Y-linked 2B
Also known as: CDY
This protein contains a chromodomain and histone acetyltransferase catalytic domain, functioning in histone hyperacetylation during spermatogenesis to facilitate the replacement of histones with protamines in developing sperm. The gene is located on the Y chromosome and is specifically expressed in late spermatids during male germ cell development. No established human genetic diseases have been definitively associated with mutations in this gene.
Population Genetics & Constraint
Constraint data not available from gnomAD.
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CDY2B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools