CDY2A

Chr Y

chromodomain Y-linked 2A

Also known as: CDY, CDY2

NCBI Gene: 9426ENSG00000182415UniProt: Q9Y6F7OMIM: 400018

This protein contains a chromodomain and histone acetyltransferase catalytic domain, functioning in histone hyperacetylation during spermatogenesis to facilitate the replacement of histones with protamines in developing sperm. CDY2A is located on the Y chromosome and is involved in male fertility, with mutations potentially contributing to male infertility or spermatogenic defects. Inheritance follows a patrilineal Y-linked pattern, passing directly from father to son.

OMIMResearchSummary from RefSeq, UniProt
Clinical Summary— CDY2A
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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CDY2A · protein map & ClinVar variants

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3D Protein StructureAlphaFold

Clinical Trials

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External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients