CDY1
Chr Ychromodomain Y-linked 1
Also known as: CDY, CDY1A
CDY1 encodes a histone acetyltransferase with chromodomain that functions specifically in late spermatids to acetylate histone H4, facilitating the replacement of histones with protamines during sperm maturation. This gene is located on the Y chromosome and mutations would follow Y-linked inheritance, passing from father to son. CDY1 mutations are associated with male infertility rather than neurological disease.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
101 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 75 |
Likely Pathogenic | — | — | — | — | 3 |
VUS | — | — | — | — | 16 |
Likely Benign | — | — | — | — | 6 |
Benign | — | — | — | — | 1 |
| Total | — | 101 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
CDY1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools