CDK14

Chr 7

cyclin dependent kinase 14

Also known as: PFTAIRE1, PFTK1

NCBI Gene: 5218ENSG00000058091UniProt: O94921

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

77
ClinVar variants
12
Pathogenic / LP
0.00
pLI score
1
Active trials
Clinical Summary— CDK14
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
12 Pathogenic / Likely Pathogenic· 60 VUS of 77 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available
Some data sources returned errors (1)

clinvar: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?LOEUF (Loss-of-function Observed/Expected Upper bound Fraction) is the upper bound of the 90% CI for LoF OE — the preferred gnomAD v4 metric. Lower = more intolerant to LoF. LOEUF < 0.35 = highly constrained.
0.95LOEUF
pLI 0.000
Z-score 1.75
OE 0.63 (0.42–0.95)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?Missense Z-score: standard deviations fewer missense variants observed vs. expected. Z > 3.09 (p < 0.001) = gene does not tolerate missense variation. OE missense < 0.6 is also considered constrained.
1.28Z-score
OE missense 0.77 (0.68–0.87)
188 obs / 244.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?Shaded band = 90% confidence interval. Vertical tick = point estimate. Grey threshold line = gnomAD constraint cutoff for that variant class.
LoF OE?Ratio of observed to expected LoF variants. Upper CI bound (LOEUF) ≤ 0.35 = strong LoF constraint signal.0.63 (0.42–0.95)
0≤0.351.4
Missense OE?Ratio of observed to expected missense variants. OE ≤ 0.6 = fewer missense variants than expected by chance.0.77 (0.68–0.87)
0≤0.61.4
Synonymous OE?Control metric — synonymous variants are largely neutral and expected near OE = 1.0. Significant deviation may indicate annotation issues.0.99
0≤1.21.6
LoF obs/exp: 16 / 25.6Missense obs/exp: 188 / 244.3Syn Z: 0.08

ClinVar Variant Classifications

77 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic11
Likely Pathogenic1
VUS60
Likely Benign3
Benign2
11
Pathogenic
1
Likely Pathogenic
60
VUS
3
Likely Benign
2
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
11
0
11
Likely Pathogenic
0
0
1
0
1
VUS
0
49
11
0
60
Likely Benign
0
0
3
0
3
Benign
0
0
0
2
2
Total04926277

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

CDK14 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
CDK14 expression is elevated in patients with non-small cell lung cancer and correlated with poor prognosis.
Yang Y et al.·J Int Med Res
2021Cohort
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.
Ferguson FM et al.·Cell Chem Biol
2019
CDK14/β-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo.
Sun Y et al.·J Gene Med
2022Functional
miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14.
Ji Q et al.·Cell Death Dis
2017
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
Kang M et al.·Mol Neurodegener
2023Meta-analysis
miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling.
Zhang G et al.·Mol Biotechnol
2024
MicroRNA-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14.
Li Q et al.·Biomed Pharmacother
2018
Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis.
Gu Z et al.·Biochem Biophys Res Commun
2018
Comprehensive transcriptomic analysis of prostate cancer lung metastases.
Saraji A et al.·PLoS One
2024
Identification of potential drug targets for achalasia from genetic insights: a Mendelian randomization study.
Xiong K et al.·J Cardiothorac Surg
2025
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Post Traumatic Stress DisorderComplex Posttraumatic Stress DisorderStress

Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

RECRUITING
NCT05701111Phase NAStanford UniversityStarted 2024-02-23
Start with the Heart StudentsStart with the Heart TeachersCue Centered Therapy Counselors

External Resources

Links to major genomics databases and tools