CDH17

Chr 8

cadherin 17

Also known as: CDH16, HPT-1, HPT1

NCBI Gene: 1015ENSG00000079112UniProt: Q12864

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

ResearchGenerating clinical summary…
8
Active trials
42
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.96
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.96LOEUF
pLI 0.000
Z-score 1.74
OE 0.70 (0.51–0.96)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.35Z-score
OE missense 0.95 (0.88–1.03)
438 obs / 459.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.70 (0.51–0.96)
0≤0.351.4
Missense OE?0.95 (0.88–1.03)
0≤0.61.4
Synonymous OE?1.08
0≤1.21.6
LoF obs/exp: 27 / 38.7Missense obs/exp: 438 / 459.2Syn Z: -0.80

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

CDH17 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Cerebral Aneurysm

Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms

RECRUITING
NCT04141020Phase PHASE2University of MiamiStarted 2021-10-27
Microsurgical clippingEndovascular treatmentSirolimus
Biliary Tract CancerColorectal CarcinomaGastric Cancer, Metastatic

CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors

RECRUITING
NCT06937567Phase EARLY_PHASE1Zhejiang UniversityStarted 2024-12-26
CDH17 CAR-TFAST LACO-Stim CDH17 CAR-T
CDH17-positive Advanced Solid Tumors

Safety and Preliminary Efficacy of Anti-CDH17 CAR-T Cell Therapy in Patients with CDH17-positive Advanced Solid Tumors

RECRUITING
NCT06820424Phase EARLY_PHASE1920th Hospital of Joint Logistics Support Force of People's Liberation Army of ChinaStarted 2025-03
Anti-CDH17 CAR-T cells infusion
AIDS-Related Kaposi SarcomaSkin Kaposi Sarcoma

Nirogacestat in Patients With Kaposi Sarcoma

NOT YET RECRUITING
NCT07539454Phase PHASE2AIDS Malignancy ConsortiumStarted 2026-09-17
Biospecimen CollectionChest RadiographyComputed Tomography
Giant Cell ArteritisTemporal ArteritisClonal Hematopoiesis of Indeterminate Potential

Clonal Hematopoiesis in Giant Cell Arteritis

NOT YET RECRUITING
NCT06244069ASST Fatebenefratelli SaccoStarted 2024-03
Temporal arterial biopsyWhole exome sequencingSingle cell transcriptomics
Non-Small Cell Carcinoma of Lung, TNM Stage 4Non-Small Cell Lung CancerEGFR Gene Mutation

Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy

RECRUITING
NCT03042221University of Colorado, DenverStarted 2016-05-10
Gastric Cancer

The Gastric Cancer Foundation: A Gastric Cancer Registry

RECRUITING
NCT01514045Stanford UniversityStarted 2011-04
ASD

Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD

RECRUITING
NCT07400484Chen LiStarted 2025-12-18

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients