CDC37L1
Chr 9cell division cycle 37 like 1, HSP90 cochaperone
Also known as: CDC37B, HARC
CDC37L1 encodes a co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90, functioning as part of the cellular protein folding machinery. The gene is highly constrained against loss-of-function variants (pLI=0.97, LOEUF=0.33), but no specific human diseases have been definitively associated with CDC37L1 mutations in the current literature. Further research is needed to establish clear genotype-phenotype correlations for this gene.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
CDC37L1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools